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Physician's Skin Solutions prescribes skin care products that clinically proven.  A leader in innovative wound-healing technologies, ProCyte has conducted controlled clinical studies at medical centers worldwide to identify the biological actions of copper peptide complexes in wound repair. These findings were the catalyst for ProCyte's breakthrough research in tissue repair, hair care and anti-aging skin care. At present, ProCyte offers more than 220 clinically proven products, all designed to 'Heal the Wounds of Time.™' Copper: An Essential Element for Life Copper is an element essential to a number of physiologic processes in the human body, yet has not enjoyed the same degree of consumer understanding as iron and zinc. The presence of copper in living tissues has been known for more than 200 years. Early medicinal applications of copper typically involved treatment of painful joints and muscles using copper bracelets, or copper-containing ointments. Scientific studies have clearly defined a role for copper in the regulation of growth, development, and function of the human body. Less than 1 mg of copper is available in the typical daily American diet. Through a complicated series of exchanges, copper finds its way into the blood system, bound primarily to ceruloplasmin. Copper is utilized by essentially every cell; resulting in the intracellular formation of copper-dependent enzymes - including cytochrome c oxidase (energy production) and superoxide dismutase (antioxidation). Copper is also essential for other enzymes including lysyl oxidase (crosslinking of elastin and collagen) and dopamine beta hydroxylase (catecholamine formation). (1) In the 1970's, scientists isolated a sequence of amino acids (glycyl-L-histidyl-L-lysine; GHK) in human serum that bound copper, and used that initial piece of information to build a peptide copper-based technology with implications in anti-aging and tissue repair processes. The tripeptide GHK was originally considered a growth factor (liver cell growth factor), and a number of journal articles resulted from this biological research. (2) ProCyte Corporation was founded in 1986 to focus on the research and development of copper peptides specifically for wound healing and hair growth. ProCyte conducted and published a number of wound healing clinical studies showing the benefits of GHK-Cu (Iamin, Prezatide Copper Acetate). (3,4) The activities of the compound were supported by research studies showing positive effects on collagen deposition (5), tensile strength (6), angiogenesis (7), and SOD activity. (8) Published studies on hair growth using a different copper peptide compound demonstrated the positive influence of copper on hair follicle cycle regulation. (9) Utilizing the knowledge that copper peptides provide a vital function relative to tissue repair, it is ProCyte's goal to provide the clinician with safe and effective wound care products to enhance the healing outcome of cosmetic surgery and hair transplant procedures, leading to a more effective procedure and improved results. The GraftCyte System and Iamin Family of products incorporate both the science of copper peptides, and the known benefits of moist wound healing. (10) References: 1) Linder MC. Biochemistry of Copper. E. Freiden, Ed. Plenum Press. 1991. 2) Schlesinger DH, et al. Growth-modulating serum tripeptide glycyl-histidyl-lysine. Experientia 33: 324. 1977. 3) Fish, et al. Evaluation of glycyl-L-histidyl-L-lysine copper complex in acute wound healing. Effects in post Mohs' surgery wounds. Wounds 3: 171. 1991. 4) Mulder, et al. Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-L-histidyl-L-lysine copper. Wound Rep and Regen 2: 259. 1994. 5) Maquart, et al. In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(II) in rat experimental wounds. J Clin Invest 92: 2368. 1993. 6) Schmidt, et al. The combined effects of glycyl-L-histidyl-L-lysine:copper (II) and cell take on the healing of linear incision wounds. Wounds 6: 62. 1994. 7) Raju, et al. Ceruloplasmin, copper ions, and angiogenesis. J Nat Cancer Inst 69. 1982. 8) Miller, et al. Effects of glycyl-histidyl-lysyl chelated Cu (II) on ferritin dependent lipid peroxidation. in Antioxidants in Therapy and Preventative Medicine. Plenum Pub Corp. 1990. 9) Trachy, et al. Phototrichogram analysis of hair follicle stimulation: a pilot clinical study with a peptide-copper complex. in Dermatologic Research Techniques. H. Maibach, Ed. CRC Press. 1996. 10)
Vogt, et al. Dry, moist, and wet skin wound repair. Ann Plas Surg 34 (5). 1995. |
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